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Professor Paul Lee
I AMRegen.Fellow.

Professor Paul Lee

MBBCh · MSc (Sports Med) · MFSEM (UK) · MRCS · FEBOT (Eu) · PhD (Medical Engineering) · FRCS (Tr & Orth)
United KingdomLondon, United Kingdom
Founding PresidentRegenerative Orthopaedic SurgeonPhD Medical Engineering

Consultant regenerative orthopaedic surgeon and Founding President of I AM Regen — a pioneer of cartilage-regeneration techniques, from single-stage STACi to bedside Nano-ACi.

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Biography

Professor Paul Lee is an internationally recognised consultant regenerative orthopaedic surgeon and Founding President of I AM Regen, specialising in cartilage repair, joint preservation, sports injuries and regenerative orthopaedics. He founded the London Cartilage Clinic on Harley Street — an ICRS Teaching Centre of Excellence — and MSK Doctors in Lincolnshire, integrating advanced imaging, artificial intelligence and regenerative therapies into patient care. His practice is built around a single question: can the joint still be saved before replacement?

He has pioneered a ladder of cartilage-regeneration techniques that progressively remove barriers to treatment — from two-stage ACI and MACI, to his single-stage STACi, which removes the need for a laboratory, and now Nano-ACi, which removes the need for an operating theatre and brings cartilage regeneration to the bedside. He is an expert in cartilage autograft, BMAC, PRF, mFat, SVF, exosomes and ChondroFiller (Liquid Cartilage), and was the first surgeon in the UK to use Arthrosamid for knee osteoarthritis, with more than 1,000 treatments.

A surgeon, scientist and engineer, Professor Lee holds a PhD in Medical Engineering and is Honorary Professor of Sports Medicine at the University of Lincoln. He has more than 100 peer-reviewed publications, is Editor-in-Chief of Springer Nature’s Musculoskeletal Regeneration Medicine, and is author of the Amazon #1 bestseller Regeneration by Design and his new book Practical Regeneration.

Selected publications

Mosaid S, Jihad Y, Jihad M, Marudanayagam A, Lee P. Articular Cartilage Tissue Engineering: Cells, Bioinstructive Scaffolds, Immunological Microenvironment, and Emerging Technologies.
Bioengineering2026
Polyacrylamide Hydrogel (Arthrosamid) Injections in Knee Osteoarthritis: A PROMs-Based 24-Month Cohort Study.
J Clin Orthop Trauma2025
Lee PYF, Nokes L, Smith PM. No effect of intravenous Actovegin on peak aerobic capacity.
Int J Sports Medicine2012

Details

GenderMale
Date of birth6 August 1980

Areas of specialism

Cartilage repair & regenerationChondroFiller & ChondromidSTACi (single-stage)Nano-ACi (bedside)BMAC · PRF · mFat · SVF · exosomesArthrosamid for knee OAACL repair (STARR)Joint preservation

Clinics & affiliations

London Cartilage Clinic
Medical Director
London, United Kingdom

Achievements & honours

Founding President, I AM Regen (IAMRegen)
Pioneer of the cartilage-regeneration ladder — STACi, Nano-ACi and Chondromid
First surgeon in the UK to perform Arthrosamid for knee osteoarthritis — 1,000+ treatments
Robert Jones Medal & Association Prize, British Orthopaedic Association (2026); NHS Long Service Award (2026)
Editor-in-Chief, Musculoskeletal Regeneration Medicine (Springer Nature); author, Regeneration by Design & Practical Regeneration; invited TEDx speaker

Declarations & interests

IAMRegen President (a programme appointment of MSK REGEN, registered charity no. 1211400).
Section Editor of Orthopedic Surgery & Trauma (ORTST), IAMRegen’s independent official publishing partner.
Founder & Medical Director, MSK Doctors / London Cartilage Clinic; Honorary Professor, University of Lincoln.
Editorial recusal: for any IAMRegen-originated submission to ORTST in which he is an author, contributor or otherwise conflicted, he is recused from handling and deciding it; an independent, unconflicted editor controls reviewer selection and the decision, and ORTST retains final editorial authority.
These overlapping roles do not guarantee publication or journal endorsement.
Last updated 9 August 2026 · Public interests register →

Meet the rest of the founders.

The Founding Five shape the science and safeguard the evidence base, acting within written delegation from the MSK REGEN trustees.

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